NEWS

  • Nature Reviews Drug Discovery
  • NIH Research Matters
  • Press Release (Malaria)
  • Press Release (IKK2)
  • Nature Cell Biol. (IKK2)
  • Press Release/Staph
  • C&EN News: Diterpene Cyclase
  • Nature Chem. Biol. on CrtM
  • 2011 Biophysical Society Award
  • C&EN News on 4Fe4S Cluster
  • Accounts of Chemical Research
  • PNAS: IspG
  • Jordan Gets ACS Scholarship Award
  • IspH PNAS in Microbe Magazine
  • Illinois News Bureau
  • RSC Award
  • C&EN
  • Chagas Clinical Results in Microbe Magazine
  • Our Pre-clinical Chagas Paper
  • Naked Scientists Podcast about Staph inhibitor
  • Nature Reviews Drug Discovery
  • New England Journal of Medicine



  •  

    Welcome Bienvenidos Welcome
    Swagatam Swagatam Welcome
     
    Our interests are to use XRD, computational chemistry, NMR, and synthesis to develop new antibiotics, anti-parasitics, and anti-cancer drugs.

    • Anti-Parasitics
    • NRC Rankings
    • Membrane NMR
    • Julio Urbina T. cruzi
    • Quantum Proteins
    • Bisphosphonate Mechanism
    • NO-Heme DFT
    • Dual Inhibitors
    • CrtM Mechanism
    • IPPI
    • Anti-Bacterials
    • Fuel Cell EC NMR
    • Pt-Rh EC NMR
    • Structure Refinement
    • UPPS Structure
    • Malaria No More
    • Actonel Chagas
    • LytB(IspH) Structure
    • Bone-Binding
    • Inorganic Solisd






    Latest 10 Publications

    433

    Malwal SR, ODowd B, Feng X, Turhanen P, Shin C, Yao J, Kim BK, Baig N, Zhou T, Bansal S, Khade RL, Zhang Y, Oldfield E.
    Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways.
    J Am Chem Soc. 2018 Jun 20;140(24):7568-7578. DOI: 10.1021/jacs.8b02363

    432

    Venkatramani A, Gravina Ricci C, Oldfield E, McCammon JA.
    Remarkable similarity in Plasmodium falciparum and Plasmodium vivax geranylgeranyl diphosphate synthase dynamics and its implication for antimalarial drug design.
    Chem Biol Drug Des. 2018 Jun;91(6):1068-1077. DOI: 10.1111/cbdd.13170

    431

    Malwal SR*, Gao J*, Hu XY*, Yang YY*, Liu WD, Huang Ko TP, Li LP, Chen CC, ODowd, B, Khade RL, Zhang Y, Zhang YH, Oldfield E, Guo, RT.
    Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes.
    ACS Catal., 2018, 8 (5), pp 4299–4312. DOI: 10.1021/acscatal.8b00543

    430

    Elsebaei MM*, Mohammad H*, Abouf M, Abutaleb NS, Hegazy YA, Ghiaty A, Chen L, Zhang J, Malwal SR, Oldfield E, Seleem MN, Mayhoub AS.
    Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA).
    Eur J Med Chem. 2018 Mar 25;148:195-209. DOI: 10.1016/j.ejmech.2018.02.031

    429

    Venkatramani A, Gravina Ricci C, Oldfield E, McCammon JA.
    Remarkable similarity in Plasmodium falciparum and Plasmodium vivax geranylgeranyl diphosphate synthase dynamics and its implication for antimalarial drug design.
    Chem Biol Drug Des. 2018 Jan 18. DOI: 10.1111/cbdd.13170

    428

    Gao J*, Ko TP*, Chen L*, Malwal SR*, Zhang J, Hu X, Qu F, Liu W, Huang JW, Cheng YS, Chen CC, Yang Y, Zhang Y, Oldfield E, Guo RT.
    "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase.
    Angew Chem Int Ed Engl. 2018 Jan 15;57(3):683-687. DOI: 10.1002/anie.201710185

    427

    X Zhou, Y Gu, H Xiao, N Kang, Y Xie, G Zhang, Y Shi, X Hu, E Oldfield, X Zhang, Yonghui Zhang
    Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells
    Front. Immunol., 24 October 2017. doi.org/10.3389/fimmu.2017.01381.

    426

    Rao G, Bansal S, Law WX, O Dowd B, Dikanov SA, Oldfield E.
    Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase.
    Biochemistry. 2017 Jul 25;56(29):3770-3779. DOI: 10.1021/acs.biochem.7b00308

    425

    Boulmier A, Feng X, Oms O, Mialane P, Rivière E, Shin CJ, Yao J, Kubo T, Furuta T, Oldfield E, Dolbecq A.
    Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results.
    Inorg Chem. 2017 Jul 3;56(13):7558-7565. DOI: 10.1021/acs.inorgchem.7b01114

    424

    Schwalen CJ, Feng X, Liu W, O-Dowd B, Ko TP, Shin CJ, Guo RT, Mitchell DA, Oldfield E.
    Head-to-Head Prenyl Synthases in Pathogenic Bacteria.
    Chembiochem. 2017 Jun 1;18(11):985-991. DOI: 10.1002/cbic.201700099.

    (c) 2010-2015 Research Group of Professor Eric Oldfield
    University of Illinois at Urbana-Champaign

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